Elucidating the mechanism
Elucidating the mechanism - physical attractiveness and communication in dating
For cancer, this knowledge could mean the development of new treatments.Recently, my lab has identified EXD2, a protein that is required for the initial key step in HR repair i.e. However, the molecular mechanism by which this novel nuclease mends broken chromosomes is unknown.
We discuss how quantum computers can augment classical computer simulations used to probe these reaction mechanisms, to significantly increase their accuracy and enable hitherto intractable simulations.
The faithful repair of DSBs is therefore essential, not only for the survival of our cells but also for our growth and development, as defective repair can cause many inherited human syndromes characterised by developmental abnormalities, cancer or premature ageing.
DSBs are also thought to be the main lesion causing cell death, a property that has been exploited for cancer treatment.
These are important issues in medical research and their understanding will have far reaching implications.
For the many inherited human disorders caused by defective DSB repair, improving our understanding could in the future lead to the development of better management and prevention strategies.
Although several dehydrogenation pathways have been proposed, the hydrogenation process is less well understood.
Although this reaction has been employed for more than 30 years, the mechanism remains unknown.
This studentship is funded by the Medical Research Council.
Normally to be eligible for a full award a student must have no restrictions on how long they can stay in the UK and have been ordinarily resident in the UK for at least 3 years prior to the start of the studentship.
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Our work addresses the question of compelling killer applications for quantum computers.
The two main ways used by our cells to repair DSBs are non–homologous end-joining (NHEJ), which involves ‘sticking’ or joining back together the two broken ends, and homologous recombination (HR), which involves a copy/paste type reaction utilizing information (DNA sequence) from an intact DNA template.